Org 48762-0

Tocris Bioscience | Catalog # 6014

Selective p38α/β inhibitor; orally bioavailable
Tocris Bioscience
Discontinued Product
6014 has been discontinued. View all p38 Inhibitors products.

Key Product Details

Description

Selective p38α/β inhibitor; orally bioavailable
View all p38 Inhibitors »

Product Description

Org 48762-0 is a selective p38α and β kinase inhibitor (EC50 = 0.1 μM for p38α). Selective for p38α/β over a panel of 48 other human kinases. Inhibits LPS-induced TNFα release from PBMCs. Also inhibits cytokine release in an LPS-induced endotoxemia model in mice. Orally bioavailable.

Product Specifications for Org 48762-0

Molecular Weight

398.41

Formula

C24H16F2N4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4,6-Bis(4-fluorophenyl)-2-methyl-5-(4-pyridinyl)-2H-pyrazolo[3,4-b]pyridine

CAS Number

755753-89-0

PubChem ID

24822135

InChI Key

VMAKTIDYMSNPOV-UHFFFAOYSA-N

SMILES

CN1C=C2C(N=C(C(C3=CC=NC=C3)=C2C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 19.92 50
DMSO 39.84 100

Preparing Stock Solutions for Org 48762-0

The following data is based on the product molecular weight 398.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.55 mL 25.10 mL
5 mM 0.50 mL 2.51 mL 5.02 mL
10 mM 0.25 mL 1.25 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.50 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for Org 48762-0

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Org 48762-0

For research use only

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