Ouabain

Key Product Details

Product Description

Ouabain is a selective Na⁺, K⁺-ATPase inhibitor. Cardiotonic agent. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC₅₀ = 0.08 μM).

Product Specifications for Ouabain

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ouabain

The following data is based on the product molecular weight 584.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.71 mL	8.55 mL	17.10 mL
5 mM	0.34 mL	1.71 mL	3.42 mL
10 mM	0.17 mL	0.86 mL	1.71 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 57 publications citing the usage of this product.

• Ko Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. BioRxiv - Paper not yet peer reviewed
• Hosoi Isoform-specific up-regulation by ouabain of Na⁺, K⁺-ATPase in cultured rat astrocytes. J.Neurochem. 1997 PMID: 9349566
• Marjorie Ouabain improves cardiac function in vivo in rats with heart failure after chronic but not acute treatment. Naunyn Schmiedebergs Arch.Pharmacol. 1997 PMID: 9272726
• Croyle Extensive random mutagenesis analysis of the Na/K⁺ ATPase alpha subunit identifies known and previously unidentified amino acid residues that alter ouabain sensitivity-implications for ouabain binding. Eur.J.Biochem. 1997 PMID: 9346307

Product Documents for Ouabain