OXF BD 02

Key Product Details

Product Description

OXF BD 02 is a selective inhibitor of the first bromodomain of BRD4 (BRD4(1)) (IC₅₀ = 382 nM). Exhibits 2-3-fold selectivity for BRD4(1) over the CBP bromodomain and has little affinity for a range of other bromodomains. Reduces viability of lung adenocarcinoma cell lines and attenuates proliferation of MV-4-11 leukemia cells. Cell permeable.

Licensing Information

Sold with the agreement of the University of Oxford

Product Specifications for OXF BD 02

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for OXF BD 02

The following data is based on the product molecular weight 295.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.39 mL	16.93 mL	33.86 mL
5 mM	0.68 mL	3.39 mL	6.77 mL
10 mM	0.34 mL	1.69 mL	3.39 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hewings Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J.Med.Chem. 2013 PMID: 23517011
• Hewings 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. J.Med.Chem. 2011 PMID: 21851057

Product Documents for OXF BD 02