Ozagrel hydrochloride

Name: Ozagrel hydrochloride
Brand: Tocris Bioscience
SKU: 1510
Price: 107 USD

Catalog #: 1510
2 Citations Datasheet / COA / SDS

Discontinued Product

1510 has been discontinued.

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Ozagrel hydrochloride | CAS No. 78712-43-3 | Additional Prostanoid Receptor Compounds

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Description: Selective thromboxane A2 synthetase inhibitor

Alternative Names: OKY 046

Chemical Name: (2E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid hydrochloride

Purity: ≥98%

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Product Details

Citations (2)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Ozagrel hydrochloride is a potent and selective inhibitor of thromboxane (TXA₂) synthetase (IC₅₀ = 4 nM). Does not inhibit prostacyclin (PGI₂) synthetase, cyclooxygenase or PGE₂ isomerase (IC₅₀ > 1 mM). Inhibits platelet aggregation in vitro and arachidonate-induced arterial contraction in vivo.

Technical Data

M.Wt:

264.71

Formula:

C₁₃H₁₂N₂O₂.HCl

Solubility:

Soluble to 100 mM in water

Purity:

≥98%

Storage:

Store at RT

CAS No:

78712-43-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets.
Naito et al.
Eur.J.Pharmacol., 1983;91:41
Pharmacological studies on the TXA₂ synthetase inhibitor (E)-3-[p-(1H-imidazol-1ylmethyl)phenyl]-2-propenoic acid (OKY-046).
Hiraku et al.
Jpn.J.Pharmacol., 1986;41:393
Participation of thromboxane A₂ in the cough response in guinea-pigs: antitussive effect of ozagrel.
Shinagawa et al.
Br.J.Pharmacol., 2000;131:266

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Citations for Ozagrel hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Ozagrel hydrochloride include:

2 Citations: Showing 1 - 2

Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging.
Authors: Wong Et al.
Circ Res 2009;104:228
Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum.
Authors: Rancillac Et al.
Proc Natl Acad Sci U S A 2006;26:6997

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