PA Nic

Key Product Details

Product Description

PA Nic is a coumarin-caged nicotine. Releases nicotine when exposed to 390 ± 10 nm wavelength light (λmax = 404 nm). Suitable for two-photon uncaging at <900 nm (Maximum two-photon cross-section at 810 nm). Extinction coefficient (ε) 17,400 M^-1cm^-1. Evokes nicotinic currents in mouse brain slices under one and two-photon activation conditions.

Product Specifications for PA Nic

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PA Nic

The following data is based on the product molecular weight 679.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	5.89 mL	29.43 mL	58.87 mL
1.25 mM	1.18 mL	5.89 mL	11.77 mL
2.5 mM	0.59 mL	2.94 mL	5.89 mL
12.5 mM	0.12 mL	0.59 mL	1.18 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Yan Nicotinic cholinergic receptors in VTA glutamate neurons modulate excitatory transmission. Cell Rep. 2018 PMID: 29791835
• Arvin Probing nicotinic acetylcholine receptor function in mouse brain slices via laser flash photolysis of photoactivatable nicotine. J.Vis.Exp. 2019 PMID: 30735191
• Banala Photoactivatable drugs for nicotinic optopharmacology. Nat.Methods 2018 PMID: 29578537

Product Documents for PA Nic