Palmitoylethanolamide

Key Product Details

Product Description

Palmitoylethanolamide is an endogenous lipid that acts as a selective GPR55 agonist (EC₅₀ values are 4, 19 800 and > 30 000 nM at GPR55, CB₂ and CB₁ receptors respectively). Substrate for fatty acid amide hydrolase (FAAH) and PEA-preferring acid amidase (PAA) and exhibits antinociceptive and anticonvulsant in vivo. Directly activates PPARα (EC₅₀ = 3 μM) producing robust anti-inflammatory actions.

Product Specifications for Palmitoylethanolamide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Palmitoylethanolamide

The following data is based on the product molecular weight 299.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	13.36 mL	66.78 mL	133.56 mL
1.25 mM	2.67 mL	13.36 mL	26.71 mL
2.5 mM	1.34 mL	6.68 mL	13.36 mL
12.5 mM	0.27 mL	1.34 mL	2.67 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 18 publications citing the usage of this product.

• Ryberg The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 2007 PMID: 17876302
• Re Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals. Vet.J. 2005 PMID: 16324856
• Lambert The palmitoylethanolamide family: a new class of anti-inflammatory agents? Curr.Med.Chem. 2002 PMID: 11945130
• Lo Verme The search for the palmitoylethanolamide receptor. Life Sci. 2005 PMID: 15963531
• Lambert Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice. Epilepsia 2001 PMID: 11442148

Product Documents for Palmitoylethanolamide