Pan Caspase OPH Inhibitor Q-VD, Non-omethylated

R&D Systems | Catalog # OPH001

R&D Systems
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Formulation, Preparation, and Storage

OPH001
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: Caspase (Pan-specific)

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Alternate Names

CASP1, caspase 1, ICE, IL1BC, p45

Additional Caspase (Pan-specific) Products

Product Documents for Pan Caspase OPH Inhibitor Q-VD, Non-omethylated

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Product Specific Notices for Pan Caspase OPH Inhibitor Q-VD, Non-omethylated

For research use only

Related Research Areas

Cysteine Proteases and Regulators

Citations for Pan Caspase OPH Inhibitor Q-VD, Non-omethylated

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FAQs for Pan Caspase OPH Inhibitor Q-VD, Non-omethylated

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  • Q: Are R&D Systems Caspase Inhibitors irreversible?

    A: Yes, the majority of R&D Systems Caspase Inhibitors have a Fluoromethyl ketone (FMK) functional group on the C-terminus of the peptide, and act as effective irreversible inhibitors with no added cytotoxic effects. Inhibitors synthesized with a benzyloxycarbonyl group (also known as BOC or Z) at the N-terminus and O-methyl side chains exhibit enhanced cellular permeability. R&D Systems also offers a General Caspase Inhibitor, Q-VD-OPh, Catalog # OPH001, as well as a FITC-conjugated pan-caspase inhibitor (ApoStat), Catalog # FMK012, which are both cell-permeable, irreversible inhibitors of caspase activity.

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