PCA 4248

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Platelet-activating factor receptor plays a role in the pathogenesis of graft-versus-host disease by regulating leukocyte recruitment, tissue injury, and lethality.
   Castor MG, Rezende BM, Resende CB, Bernardes PT, Cisalpino D, Vieira AT, Souza DG, Silva TA, Teixeira MM, Pinho V
   J. Leukoc. Biol., 2012;91(4):629-39.
3. Pharmacological actions of PCA 4248, a new platelet-activating factor receptor antagonist: in vivo studies.
   Fernandez-Gallardo et al.
   J.Pharmacol.Exp.Ther., 1990;255:34
4. 4-Alkyl-1,4-dihydropyridine derivatives as specific PAF-acether antagonists.
   Sunkel et al.
   J.Med.Chem., 1990;33:3205
5. 1,4-Dihydropyridines, a new class of platelet activating factor receptor antagonists: in vitro pharmacological studies.
   Sunkel et al.
   J.Pharmacol.Exp.Ther., 1990;255:28

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