PD 166285 dihydrochloride
Chemical Name: 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride
Purity: ≥99%
Biological Activity
PD 166285 dihydrochloride is a potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β (PDGFRβ) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G2 checkpoint.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor.
Panek et al.
J.Pharmacol.Exp.Ther., 1997;283:1433 -
Radiosensitization of p53 mutant cells by PD0166285, a novel G2 checkpoint abrogator.
Wang et al.
Cancer Res., 2001;61:8211 -
Cell cycle regulation by the Wee1 inhibitor PD0166285, Pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line.
Hashimoto et al.
BMC Cancer, 2006;6:292
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Citations for PD 166285 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for PD 166285 dihydrochloride include:
2 Citations: Showing 1 - 2
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Echinoderm Microtubule Associated Protein Like 1 Is Indispensable for Oocyte Spindle Assembly and Meiotic Progression in Mice.
Authors: Hui Et al.
Front Cell Dev Biol 2021;9:687522
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A critical balance between Cyclin B synthesis and Myt1 activity controls meiosis entry in Xenopus oocytes.
Authors: Gaffré Et al.
Toxicol Lett 2011;138:3735
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