Pep 2-8

Name: Pep 2-8
Brand: Tocris Bioscience
SKU: 6423
Price: 176 USD
Availability: InStock

Tocris Bioscience | Catalog # 6423

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Product Documents

Potent PCSK9 inhibitor

Technical Data
Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent PCSK9 inhibitor

View all Additional Synthetic Protease Inhibitors »

Product Description

Pep 2-8 is a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC₅₀ = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.

Product Specifications for Pep 2-8

Molecular Weight

1715.88

Formula

C₈₃H₁₁₀N₁₆O₂₄

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

1541011-97-5

PubChem ID

124221781

InChI Key

ORPZALWAWWEEDP-NXXUBLNKSA-N

SMILES

CC(C)C[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in PBS (pH 7.4)

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

音量

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Concentration 1 (C1)

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Concentration 2 (C2)

Volume 2 (V2)

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Volume (to add to vial)

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Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product.

Zhang Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J.Biol.Chem. 2014 PMID: 24225950

Product Documents for Pep 2-8

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Pep 2-8

For research use only

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