Perlapine

Key Product Details

Product Description

Perlapine is a potent muscarinic DREADD agonist (pEC₅₀ values are 8.38, 8.08 and 7.27 for hM₁D_q, hM₃D_q and hM₄D_i in vitro, respectively). Exhibits >10,000-fold selectivity for hM₃D_q over hM₃ receptors.

Product Specifications for Perlapine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Perlapine

The following data is based on the product molecular weight 291.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.86 mL	34.32 mL	68.64 mL
2.5 mM	1.37 mL	6.86 mL	13.73 mL
5 mM	0.69 mL	3.43 mL	6.86 mL
25 mM	0.14 mL	0.69 mL	1.37 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Thompson DREADD agonist 21 (C21) is an effective agonist for muscarinic-based DREADDs in vitro and in vivo. ACS Pharmacol.Transl.Sci. 2018 PMID: 30868140
• Chen The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem.Neurosci. 2015 PMID: 25587888

Product Documents for Perlapine