Pertussis Toxin

Tocris Bioscience | Catalog # 3097

Catalyzes ADP-ribosylation of Gi, Go and Gt
Tocris Bioscience

Key Product Details

Description

Catalyzes ADP-ribosylation of Gi, Go and Gt
View all G Protein (Heterotrimeric) Inhibitors »

Product Description

Pertussis Toxin is a bacterial toxin that catalyzes ADP-ribosylation of G-proteins Gi, Go and Gt. Impairs G protein heterotrimer interaction with receptors, blocking receptor coupling. Pertussis Toxin protects against ischemic stroke in a mouse model of permanent middle cerebral artery occlusion. Pertussis Toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an experimental autoimmune encephalomyelitis mouse model.

Product Specifications for Pertussis Toxin

Storage

Store at +4°C

CAS Number

70323-44-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Product Documents for Pertussis Toxin

Certificate of Analysis

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Product Specific Notices for Pertussis Toxin

For research use only

Citations for Pertussis Toxin

Customer Reviews for Pertussis Toxin (3)

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  • Pertussis toxin impacts GABA-A receptor effects
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Verified Customer | Posted 07/21/2019
    Pertussis toxin (PeTX) was used to compare effects of PKA and G-protein signalling on root mean square noise (RMS) produced by GABA-A receptors in electrophysiological recording. We found that after block of G-protein signalling with PeTX GABA-A receptor antagonists SR 95531 and Picrotoxin generate smaller impact on RMS noise than after block of PKA with PKI.
    Pertussis Toxin 3097
  • Pertussis Toxin inhibits LPA induced COX-2 expression in osteosarcoma cells
    Name: Christopher Trummer
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Osteosarcoma
    Verified Customer | Posted 10/23/2018
    MG-63 cells were treated with LPA (10 µM) alone or in combination with C3 (20 µM), PTX (Pertussis Toxin, 400 ng/ml) or H2L 5765834 (20 µM) for 3 h to follow COX-2 expression using Western blot. Pertussis Toxin inhibited COX-2 expression induced by LPA.
    Pertussis Toxin 3097
  • Fast delivery and great quality
    Name: Anonymous
    Assay Type: In Vitro
    Cell Line/Tissue: CHO-KK1
    Verified Customer | Posted 07/17/2017
    It was used to block gpcr response before hitting the cells with the ligand for receptor of interest

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