Chemical Name: 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide
Biological ActivityPF 184 is a potent and selective IKKβ inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1β-induced TNF-α production in a steroid-insensitive in vitro model of oxidative stress.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Citations for PF 184
The citations listed below are publications that use Tocris products. Selected citations for PF 184 include:
3 Citations: Showing 1 - 3
In vitro benchmarking of NF-κB inhibitors.
Authors: Charles Et al.
Eur J Pharmacol 2020;873:172981
Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING.
Authors: Michael Et al.
Mol Cell 2019;74:801-815.e6
Bindarit: an anti-inflammatory small molecule that modulates the NFκB pathway.
Authors: Mora Et al.
Cell Cycle 2012;11:159
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for PF 184
There are currently no reviews for this product. Be the first to review PF 184 and earn rewards!
Have you used PF 184?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image