PF 4708671

Tocris Bioscience | Catalog # 4032

S6K1 inhibitor
Tocris Bioscience

Key Product Details

Description

S6K1 inhibitor
View all RSK Inhibitors »

Product Description

PF 4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) (Ki = 20 nM; IC50 = 160 nM). Suppresses the S6K1-mediated phosphorylation of S6, Rictor and mTOR in response to IGF1; displays no effect on the activity of RSK and MSK in vivo. Exhibits no significant inhibition of S6K2 or other AGC kinases (e.g. Akt, PKA and ROCK) in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 4708671

Molecular Weight

390.41

Formula

C19H21F3N6

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole

CAS Number

1255517-76-0

PubChem ID

51371303

InChI Key

FBLPQCAQRNSVHB-UHFFFAOYSA-N

SMILES

CCC(C=NC=N2)=C2N1CCN(CC4=NC3=CC(C(F)(F)F)=CC=C3N4)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.52 50
Ethanol 19.52 50

Preparing Stock Solutions for PF 4708671

The following data is based on the product molecular weight 390.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.12 mL 25.61 mL 51.23 mL
2.5 mM 1.02 mL 5.12 mL 10.25 mL
5 mM 0.51 mL 2.56 mL 5.12 mL
25 mM 0.10 mL 0.51 mL 1.02 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 46 publications citing the usage of this product.

Product Documents for PF 4708671

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 4708671

For research use only

Customer Reviews for PF 4708671 (1)

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  • test
    Name: Kishor Pant
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Du145 and HepG2, Huh&
    Verified Customer | Posted 08/19/2025
    We found that 5 um for 24 to 48 hours was effective.
    This compound can reduce tumour cell growth by inhibiting S6K phosphorylation.
    PF 4708671 4032

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