PF 5006739

Key Product Details

Product Description

PF 5006739 is a potent casein kinase 1δ/ε inhibitor (IC₅₀ values are 3.9 and 17 nM, respectively). Mediates circadian rhythm phase-delaying effects in vivo. Attenuates opioid drug seeking behavior in addiction in vivo models.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 5006739

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PF 5006739

The following data is based on the product molecular weight 419.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.92 mL	23.84 mL
5 mM	0.48 mL	2.38 mL	4.77 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wager Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior. ACS Chem.Neurosci. 2014 PMID: 25299732

Product Documents for PF 5006739