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PF 514273

Catalog #: 3676
1 Citation Datasheet / COA / SDS

Discontinued Product

3676 has been discontinued.
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PF 514273 | CAS No. 851728-60-4 | Cannabinoid R1/CB1 Antagonists
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Description: High affinity and selective CB1 antagonist

Chemical Name: 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PF 514273 is a high affinity and selective CB1 receptor antagonist (Ki values are 1 and > 10000 nM at CB1 and CB2 receptors respectively). Inhibits food intake in vivo following oral administration.

Technical Data

M.Wt:
452.28
Formula:
C21H17Cl2F2N3O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
851728-60-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for PF 514273

The citations listed below are publications that use Tocris products. Selected citations for PF 514273 include:

1 Citation: Showing 1 - 1

  1. AT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II.
    Authors: Rozenfeld Et al.
    EMBO J  2011;30:2350

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