PF 514273

Tocris Bioscience | Catalog # 3676

High affinity and selective CB1 antagonist
Tocris Bioscience
Discontinued Product
3676 has been discontinued. View all Cannabinoid R1/CB1 Antagonists products.

Key Product Details

Description

High affinity and selective CB1 antagonist
View all Cannabinoid R1/CB1 Antagonists »

Product Description

PF 514273 is a high affinity and selective CB1 receptor antagonist (Ki values are 1 and > 10000 nM at CB1 and CB2 receptors respectively). Inhibits food intake in vivo following oral administration.

Product Specifications for PF 514273

Molecular Weight

452.28

Formula

C21H17Cl2F2N3O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one

CAS Number

851728-60-4

PubChem ID

11316919

InChI Key

FJMQJSUOOGOWBD-UHFFFAOYSA-N

SMILES

O=C2C1=NN(C4=CC=CC=C4Cl)C(C3=CC=C(Cl)C=C3)=C1OCCN2CC(C)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.23 100
Ethanol 22.61 50

Preparing Stock Solutions for PF 514273

The following data is based on the product molecular weight 452.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.06 mL 22.11 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
10 mM 0.22 mL 1.11 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 57 publications citing the usage of this product.

Product Documents for PF 514273

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 514273

For research use only

Related Research Areas

Bioactive Lipids and Receptors

Customer Reviews for PF 514273 (1)

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  • Works as described
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 05/14/2019
    Drug can be difficult to get into solution, as would be expected for a cannabinoid compound. So don't expect to use high concentrations unless you are OK w/ using in suspension.
    Used in vivo for mouse behavioral work to test CB1 receptor involvement in alcohol reward learning and seeking behavior. Data show product did work centrally, as it reduced locomotor activity.
    PF 514273 3676

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