PF 573228

Tocris Bioscience | Catalog # 3239

Potent and selective FAK inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective FAK inhibitor
View all Focal Adhesion Kinase Inhibitors »

Product Description

PF 573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50 = 4 nM). Displays 50 - 250-fold selectivity for FAK over other protein kinases. Blocks serum and fibronectin-directed migration and decreases focal adhesion turnover in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 573228

Molecular Weight

491.49

Formula

C22H20F3N5O3S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone

CAS Number

869288-64-2

PubChem ID

11612883

InChI Key

HESLKTSGTIBHJU-UHFFFAOYSA-N

SMILES

O=C(N3)CCC1=C3C=CC(NC2=NC(NCC4=CC=CC(S(=O)(C)=O)=C4)=C(C(F)(F)F)C=N2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.15 100

Preparing Stock Solutions for PF 573228

The following data is based on the product molecular weight 491.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.17 mL 20.35 mL
5 mM 0.41 mL 2.03 mL 4.07 mL
10 mM 0.20 mL 1.02 mL 2.03 mL
50 mM 0.04 mL 0.20 mL 0.41 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 193 publications citing the usage of this product.

Product Documents for PF 573228

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 573228

For research use only

Customer Reviews for PF 573228 (3)

4.7 out of 5
3 Customer Ratings
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  • Cell cultures with ECM proteins, integrin blockade and In vitro drug treatments
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: rat astroglioma C6 cells
    Verified Customer | Posted 03/24/2020
    pharmacological antagonists of FAK for 4 h before RNA or protein isolation. FAK antagonists were PF573228
    PF 573228 3239
  • Inhibitor of FAK and effects on E0771 extracellular flux
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: E0771
    Verified Customer | Posted 10/10/2018
    Extracellular flux analysis (Seahorse experiments) of breast cancer cells. 5uM dose used for 48hrs
  • Inhibiting FAK expression in 2D and 3D cell culture
    Name: Aesha Desai
    Species: Human
    Verified Customer | Posted 01/04/2018
    Effective at inhibiting FAK expression when used in 2D (monolayer) and 3D (spheroid/microtissue) cell culture

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