PF 6274484

Key Product Details

Product Description

PF 6274484 is a high affinity and potent covalent EGFR kinase inhibitor (K_i = 0.14 nM). Inhibits autophosphorylation of WT and mutant EGFR in tumor cells (IC₅₀ values are 5.8 and 6.6 nM, respectively).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 6274484

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PF 6274484

The following data is based on the product molecular weight 372.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.41 mL	26.83 mL
5 mM	0.54 mL	2.68 mL	5.37 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Schwartz Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance. Proc.Natl.Acad.Sci.U.S.A. 2014 PMID: 24347635

Product Documents for PF 6274484