PFI 4

Key Product Details

Product Description

PFI 4 is a potent and selective BRPF1B bromodomain inhibitor (IC₅₀ = 172 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. Disrupts BRPF1 binding to histone H3.3. Cell permeable. Inhibits osteoclastogenesis.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the PFI 4 probe summary on the SGC website.

Product Specifications for PFI 4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PFI 4

The following data is based on the product molecular weight 380.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.26 mL	26.29 mL	52.57 mL
2.5 mM	1.05 mL	5.26 mL	10.51 mL
5 mM	0.53 mL	2.63 mL	5.26 mL
25 mM	0.11 mL	0.53 mL	1.05 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Meier Selective targeting of bromodomains of the bromodomain-PHD fingers family impairs osteoclast differentiation. ACS Chem.Biol. 2017 PMID: 28849908
• Demont 1,3-Dimethyl Benzimidazolones are potent, selective inhibitors of the BRPF1 bromodomain. ACS Med.Chem.Lett. 2014 PMID: 25408830

Product Documents for PFI 4