PH 797804

Key Product Details

Product Description

PH 797804 is a potent and selective p38α/β inhibitor (IC₅₀ values are 26 and 102 nM, respectively). Exhibits >100-fold selectivity for p38α/β over 71 other kinases, enzymes and GPCRs, including p38γ, p38δ, JNK and ERK2. Inhibits LPS-induced TNFα production in U937 monocytes in vitro. Suppresses acute and chronic inflammatory responses in rat models of arthritis. Orally active.

PH 797804 is the (-)-atropisomer, which is 100-fold more potent than its (+)-atropisomer.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Product Specifications for PH 797804

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PH 797804

The following data is based on the product molecular weight 477.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.19 mL	20.95 mL	41.90 mL
2.5 mM	0.84 mL	4.19 mL	8.38 mL
5 mM	0.42 mL	2.10 mL	4.19 mL
25 mM	0.08 mL	0.42 mL	0.84 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Selness Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase. Bioorg.Med.Chem.Lett. 2011 PMID: 21641211
• Hope Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation. J.Pharmacol.Exp.Ther. 2009 PMID: 19720877

Product Documents for PH 797804