Philanthotoxin 74

Key Product Details

Product Description

Philanthotoxin 74 is an AMPA receptor antagonist. Non-selective homomeric GluA3 and GluA1 receptor antagonist (IC₅₀ values are 263 and 296 nM respectively). Inhibits homomeric GluA3 and GluA1 with a 100-fold greater potency than heteromeric GluA1/2 and GluA2/3 receptors.

Product Specifications for Philanthotoxin 74

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Philanthotoxin 74

The following data is based on the product molecular weight 507.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.97 mL	9.85 mL	19.70 mL
5 mM	0.39 mL	1.97 mL	3.94 mL
10 mM	0.20 mL	0.99 mL	1.97 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 22 publications citing the usage of this product.

• Poulsen Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors. Mol.Pharmacol. 2013 PMID: 24220009
• Nilsen and England A subtype-selective, use-dependent inhibitor of native AMPA receptors. J.Am.Chem.Soc. 2007 PMID: 17391037

Product Documents for Philanthotoxin 74