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Phlorizin

Catalog #: 4627
1 Citation Datasheet / COA / SDS

Discontinued Product

4627 has been discontinued.
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Phlorizin | CAS No. 60-81-1 | Other Ion Pump/Transporter Inhibitors
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Description: Na+-glucose cotransporter (SGLT) inhibitor

Chemical Name: 1-[2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone

Purity: ≥99%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Inhibitor of Na+-glucose cotransporters (SGLT). Produces renal glycosuria and blocks intestinal glucose absorption. Normalizes insulin sensitivity in diabetic rats.

Technical Data

M.Wt:
436.41
Formula:
C21H24O10
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
60-81-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to Ins in diabetic rats.
    Rossetti et al.
    J.Clin.Invest., 1987;79:1510
  2. Phlorizin: a review.
    Ehrenkranz et al.
    Diabetes Metab Res Rev., 2005;21:31
  3. Renal Na+-glucose cotransporters.
    Wright
    Am.J.Physiol.Renal.Physiol., 2001;280:F10

Product Datasheets

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Citation for Phlorizin

The citations listed below are publications that use Tocris products. Selected citations for Phlorizin include:

1 Citation: Showing 1 - 1

  1. T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways.
    Authors: Smith Et al.
    Mol Metab  2018;17:98

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