(+)-Fluprostenol is a prostaglandin F_2α (FP) receptor agonist (K_i = 49.9 nM; EC₅₀ = 2.4 nM). Stimulates intracellular calcium mobilization in cloned human ocular FP receptors, rat A7r5 cells and mouse 3T3 cells (EC₅₀ values are 17.5, 19.1 and 37.3 nM respectively). Analog of prostaglandin F_2α. Isopropyl ester travaprost (Cat. No. 4218) also available.

Product Specifications for (+)-Fluprostenol

Molecular Weight

458.47

Formula

C₂₃H₂₉F₃O₆

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic acid

CAS Number

54276-17-4

PubChem ID

5311100

InChI Key

WWSWYXNVCBLWNZ-QIZQQNKQSA-N

SMILES

O[C@@H]1C[C@H](O)[C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)COC2=CC=CC(C(F)(F)F)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 10mg/ml)

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Background References

References are publications that support the biological activity of the product.

Sharif Human trabecular meshwork cell responses induced by bimatoprost, travoprost, unoprostone, and other EP prostaglandin receptor agonist analogues. Invest.Ophthalmol.Vis.Sci. 2003 PMID: 12556403
Kelly Real-time intracellular Ca²⁺ mobilization by travo. acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat and cloned human FP prostaglandin receptors. J.Pharmacol.Exp.Ther. 2003 PMID: 12490597

Product Documents for (+)-Fluprostenol

Certificate of Analysis

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Download SDS

Product Specific Notices for (+)-Fluprostenol

For research use only

Related Research Areas

Bioactive Lipids and Receptors

Eicosanoids and Regulators

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(+)-Fluprostenol

Tocris Bioscience | Catalog # 4542

Key Product Details

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Product Description