(+)-JQ1 maleimide

Tocris Bioscience | Catalog # 7576

JQ1-maleimide functionalized probe; induces proteasomal degradation of BRD4
Tocris Bioscience

Key Product Details

Description

JQ1-maleimide functionalized probe; induces proteasomal degradation of BRD4
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Product Description

(+)-JQ1 maleimide is a probe that comprises a cysteine-reactive maleimide connected to the BRD4 ligand, JQ1, via a PEG2 linker. It can be used in the COFFEE method (COvalent Functionalization Followed by E3 Electroporation) in which (+)-JQ1 maleimide is covalently attached to VHL followed by electroporation into live cells. The E3 ligase forms a complex with BRD4 intracellularly and induces its degradation.

Product Specifications for (+)-JQ1 maleimide

Molecular Weight

724.27

Formula

C35H42ClN7O6S

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(S)-N-(2-(2-(2-(2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)ethoxy)ethoxy)ethyl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide

InChI Key

SGQDAIFBYPRIDQ-MHZLTWQESA-N

SMILES

ClC1=CC=C(C2=N[C@@H](CC(NCCOCCOCCNC(CCCCCN3C(C=CC3=O)=O)=O)=O)C4=NN=C(C)N4C5=C2C(C)=C(C)S5)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 72.43 100

Preparing Stock Solutions for (+)-JQ1 maleimide

The following data is based on the product molecular weight 724.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.38 mL 6.90 mL 13.81 mL
5 mM 0.28 mL 1.38 mL 2.76 mL
10 mM 0.14 mL 0.69 mL 1.38 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for (+)-JQ1 maleimide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (+)-JQ1 maleimide

For research use only

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