PMX 205

Tocris Bioscience | Catalog # 5196

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Citations (24)

Product Documents

Potent C5a receptor peptide antagonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Potent C5a receptor peptide antagonist

View all Complement Signaling inhibitors »

Product Description

PMX 205 is a potent C5a receptor peptide antagonist (IC₅₀ = 31 nM). Ameliorates experimentally-induced colon inflammation in mice. Reduces fibrillar amyloid deposits, decreases hyperphosphorylated tau levels and rescues cognitive function in a mouse model of Alzheimer's disease. Also improves hindlimb grip strength and slows disease progression in the hSOD1^G93A mouse model of amyotrophic lateral sclerosis. Orally active and brain penetrant.

Product Specifications for PMX 205

Molecular Weight

839.05

Formula

C₄₅H₆₂N₁₀O₆

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

514814-49-4

PubChem ID

90489023

InChI Key

YUIBSMOWXFHTBD-UHFFFAOYSA-N

SMILES

NC(=N)NCCCC1NC(=O)C(CC2C=NC3=CC=CC=C23)NC(=O)C(CC2CCCCC2)NC(=O)C2CCCN2C(=O)C(CCCNC1=O)NC(=O)CCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water with sonication

Calculators

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Mass

Concentration

音量

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g/mol

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 24 publications citing the usage of this product.

Kumar Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice. Sci.Rep. 2018 PMID: 29802264
Lee Pharmacological inhibition of complement C5a-C5a₁ receptor signalling ameliorates disease pathology in the hSOD1^G93A mouse model of amyotrophic lateral sclerosis. Br.J.Pharmacol. 2017 PMID: 28128456
Fonseca Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J.Immunol. 2009 PMID: 19561098
Jain The C5a receptor antagonist PMX205 ameliorates experimentally induced colitis associated with increased IL-4 and IL-10. Br.J.Pharmacol. 2013 PMID: 22924972
March Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity. Mol.Pharmacol. 2004 PMID: 15044616

Product Documents for PMX 205

Certificate of Analysis

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Product Specific Notices for PMX 205

For research use only

Related Research Areas

Complement Pathway

Serine Proteases and Regulators

Citations for PMX 205

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