PMX 53

Tocris Bioscience | Catalog # 5473

Potent C5a receptor antagonist
Tocris Bioscience

Key Product Details

Description

Potent C5a receptor antagonist
View all Complement Signaling inhibitors »

Product Description

PMX 53 is a potent C5a receptor antagonist (IC50 = 20 nM). Also MrgX2 agonist. Stimulates MrgX2-mediated mast cell degranulation. Also inhibits C5a-induced hypernociception in rats, inhibits lung metastasis in a mouse breast cancer model and reduces atherosclerotic lesions in a mouse model of atherosclerosis.

Negative Control also available.

Product Specifications for PMX 53

Molecular Weight

896.10

Formula

C47H65N11O7

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

219639-75-5

PubChem ID

23526550

InChI Key

YOKBGCTZYPOSQM-UHFFFAOYSA-N

SMILES

NC(=NCCCC1NC(=O)C(NC(=O)C(CC2CCCCC2)NC(=O)C2N(C(=O)C(CCCNC1=O)NC(=O)C(Cc1ccccc1)NC(=O)C)CCC2)Cc1c[nH]c2c1cccc2)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 2mg/ml in water

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Product Documents for PMX 53

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PMX 53

For research use only

Customer Reviews for PMX 53 (1)

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  • test
    Name: Xiaogang Wang
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: neutrophils
    Verified Customer | Posted 06/22/2021
    We used this inhibitor to study the biological activity of staphylococcal leukocidin PVL, which uses C5aR as a receptor to target host immune cells. We treated neutrophils with different concentrations (2.5, 5, and 10 uM) of pmx-53 for 1 h before incubated with 1 ug/ml PVL, and the cytotoxicity of treated cells was measured by LDH assay kit. As expected, pmx-53 treatment resulted in a dose-dependent reduction of PVL cytotoxicity to neutrophils.
    PMX 53 5473

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