PNU 142633

Key Product Details

Product Description

PNU 142633 is a very selective, high affinity 5-HT_1D receptor agonist (K_i values are 6 and > 18000 nM at human 5-HT_1D and 5-HT_1B receptors respectively). Inhibits sympathetically-induced tachycardic responses and blocks neurogenic plasma protein extravasation in vivo.

Product Specifications for PNU 142633

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PNU 142633

The following data is based on the product molecular weight 422.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.83 mL	23.67 mL
5 mM	0.47 mL	2.37 mL	4.73 mL
10 mM	0.24 mL	1.18 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 44 publications citing the usage of this product.

• Sanchez-Lopez Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT₁ and putative 5-ht_5A/5B receptors. Br.J.Pharmacol. 2003 PMID: 14504136
• Roon Bovine isolated middle cerebral artery contractions to antimigraine drugs. Naunyn-Schmied.Arch.Pharmacol.
• McCall Preclinical studies characterizing the anti-migraine and cardiovascular effects of the selective 5-HT_1D receptor agonist PNU-142633. Cephalalgia 2002 PMID: 12485205

Product Documents for PNU 142633