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PNU 96415E

Catalog #: 2735
1 Citation Datasheet / COA / SDS

Discontinued Product

2735 has been discontinued.
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PNU 96415E | CAS No. 170856-41-4 | Dopamine D4 Receptor Antagonists
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Description: D4 and 5-HT2A antagonist; antipsychotic

Chemical Name: 1-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-4-(4-fluorophenyl)piperazine dihydrochloride

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

PNU 96415E is an antipsychotic agent. Displays high affinity for dopamine D4 and serotonergic 5-HT2A receptors and relatively weak affinity at D2 receptors (Ki values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D4, 5-HT2A, 5-HT1A, α1, D2, D3, D1, α2 and muscarinic receptors respectively). Inhibits exploratory locomotor activity and antagonizes d-amphetamine-induced locomotor stimulation in rats.

Technical Data

M.Wt:
413.36
Formula:
C21H25FN2O.2HCl
Solubility:
Soluble to 10 mM in water
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
170856-41-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for PNU 96415E

The citations listed below are publications that use Tocris products. Selected citations for PNU 96415E include:

1 Citation: Showing 1 - 1

  1. Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.
    Authors: Dolma Et al.
    Cancer Cell  2016;29:859

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