POM 1

Tocris Bioscience | Catalog # 2689

Inhibitor of E-NTPDases
Tocris Bioscience

Key Product Details

Description

Inhibitor of E-NTPDases

Alternative Names

Sodium polyoxotungstate
View all NTPDase Inhibitors »

Product Description

POM 1 is an inhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y12 (Ki values are 2.58, 3.26, > 10 and 28.8 μM for NTPDase 1, NTPDase 3, P2Y12 and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse.

Product Specifications for POM 1

Molecular Weight

2986.01

Formula

H2O40Na6W12

Storage

Store at RT

Chemical Name

Sodium metatungstate

CAS Number

12141-67-2

PubChem ID

71311259

InChI Key

YVQUUPJGDSQKML-UHFFFAOYSA-N

SMILES

O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 298.6 100

Preparing Stock Solutions for POM 1

The following data is based on the product molecular weight 2986.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.33 mL 1.67 mL 3.35 mL
5 mM 0.07 mL 0.33 mL 0.67 mL
10 mM 0.03 mL 0.17 mL 0.33 mL
50 mM 0.01 mL 0.03 mL 0.07 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 83 publications citing the usage of this product.

Product Documents for POM 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for POM 1

For research use only

Customer Reviews for POM 1 (1)

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  • POM-1 inhibits PBMCs CD39 activity
    Name: Anonymous
    Species: Human
    Assay Type: Ex Vivo
    Cell Line/Tissue: PBMCs
    Verified Customer | Posted 02/21/2019
    PBMCs were isolated from healthy subjects and from multiple sclerosis patients and CD39 activity was measured by the Malachite Green Phosphate Assay. Cells were washed in phosphate-free buffer and incubated with ATP (250 μM) for 30 minutes at 37ºC. To selectively assess CD39 ATPase activity, POM-1 (10 μM) was added while cells were incubated with ATP.
    Human PBMCs were incubated with 10 μM POM-1 for 30 minutes to inhibit CD39 ATPase activity. POM-1 caused a 80% inhibition of PBMCs ATPase activity.
    POM 1 2689

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