Chemical Name: 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Biological ActivityPP 3 is a negative control for the Src kinase inhibitor, PP 2. Inhibits EGFR kinase (IC50 = 2.7 μM).
Active Analog also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines.
Traxler et al.
Citations for PP 3
The citations listed below are publications that use Tocris products. Selected citations for PP 3 include:
7 Citations: Showing 1 - 7
Mathematical model of early Reelin-induced Src family kinase-mediated signaling.
Authors: Hass Et al.
PLoS One 2017;12:e0186927
Progesterone receptor membrane component-1 regulates hepcidin biosynthesis.
Authors: Li Et al.
J Clin Invest 2016;126:389
Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages.
Authors: Vijayakumar Et al.
Neural Regen Res 2015;128:251
mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
Authors: Kubota Et al.
PLoS One 2014;9:e106316
Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue.
Authors: Rosas Et al.
BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals.
Authors: Chen Et al.
Eur J Neurosci 2014;39:1439
Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment.
Authors: Kupferman Et al.
J Neuroimmune Pharmacol 2014;158:1335
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