PPAHV

Name: PPAHV
Brand: Tocris Bioscience
SKU: 1466

Tocris Bioscience | Catalog # 1466

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Product Documents

TRPV agonist

Discontinued Product

1466 has been discontinued. View all TRPV Agonists products.

Technical Data
Reviews

Product Description
Product Specifications
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

TRPV agonist

Alternative Names

Phorbol 12-phenylacetate 13-acetate 20-homovanillate

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Product Description

PPAHV is a non-pungent vanilloid TRPV1 (VR1) receptor agonist (K_i = 3.1 μM) that displays non-cooperative binding. Induces apoptosis via a non-VR1 mechanism in Jurkat cells and causes vasoconstriction in vivo.

Product Specifications for PPAHV

Molecular Weight

688.77

Formula

C₃₉H₄₄O₁₁

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

[(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-1,1,6,8-tetramethyl-5-oxo-9-[phenylacetyl)oxy]-1H-cyclopropa[3,4]benz[1,2-e]azulen-3-yl]methyl ester benzeneacetic acid

CAS Number

175796-50-6

PubChem ID

3035862

InChI Key

OGRGWTXWAZBJKF-JXWJAAHMSA-N

SMILES

O=C1C(C)=C[C@]2([H])[C@@](O)1CC(COC(CC5=CC(OC)=C(O)C=C5)=O)=C[C@]3([H])[C@@](O)2[C@H](C)[C@@H](OC(CC6=CC=CC=C6)=O)[C@]4(OC(C)=O)[C@]([H])3C(C)4C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

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音量

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Background References

References are publications that support the biological activity of the product.

Macho Phorboid 20-homovanillates induce apoptosis through a VR1-independent mechanism. Chem.Biol. 2000 PMID: 10903936
Szallasi A novel agonist, phorbol 12-phenylacetate 13-acetate 20-homovanillate, abolishes positive cooperativity of binding by the vanilloid receptor. Eur.J.Pharmacol. 1996 PMID: 8901026
Griffiths Functional and desensitizing effects of the novel synthetic vanilloid-like agent 12-phenylacetate 13-acetate 20-homovanillate (PPAHV) in the perfused rat hindlimb. Br.J.Pharmacol. 2000 PMID: 11090114

Product Documents for PPAHV

Certificate of Analysis

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Product Specific Notices for PPAHV

For research use only

Related Research Areas

Ion Channels and Regulators

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