PR 619

Tocris Bioscience | Catalog # 4482

Broad spectrum DUB inhibitor
Tocris Bioscience

Key Product Details

Description

Broad spectrum DUB inhibitor
View all Deubiquitinating Enzyme Inhibitors »

Product Description

PR 619 is a broad spectrum, reversible DUB inhibitor. Exhibits limited activity against other proteases. Induces accumulation of polyubiquitinated proteins, but has no direct inhibitory effect on the proteasome. Cytotoxic in HEK293T and colorectal cancer cells. Stabilizes microtubule network in oligodendroglial cells.

Product Specifications for PR 619

Molecular Weight

223.28

Formula

C7H5N5S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2,6-Diamino-3,5-dithiocyanopyridine

CAS Number

2645-32-1

PubChem ID

2817763

InChI Key

ZXOBLNBVNROVLC-UHFFFAOYSA-N

SMILES

NC1=C(SC#N)C=C(SC#N)C(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.23 10

Preparing Stock Solutions for PR 619

The following data is based on the product molecular weight 223.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 44.79 mL 223.93 mL 447.87 mL
0.5 mM 8.96 mL 44.79 mL 89.57 mL
1 mM 4.48 mL 22.39 mL 44.79 mL
5 mM 0.90 mL 4.48 mL 8.96 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

Product Documents for PR 619

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PR 619

For research use only

Related Research Areas

Deubiquitinating Enzymes (DUBs)

Customer Reviews for PR 619 (1)

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  • 10 uM PR-619
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: rat hippocampal neuronal
    Verified Customer | Posted 12/23/2019
    Cells cultured with 10 uM PR-619
    PR 619 4482

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