Prasugrel

Key Product Details

Product Description

Prasugrel is an irreversible P2Y₁₂ antagonist; metabolised to active metabolite R-99224 (IC₅₀ = 45 μM) irreversibly binds platelet P2Y₁₂ receptors, inhibiting platelet activation. Antiplatelet and antithrombotic. Orally active and active in vivo. Note - inactive in vitro.

Product Specifications for Prasugrel

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Prasugrel

The following data is based on the product molecular weight 373.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.39 mL	26.78 mL
5 mM	0.54 mL	2.68 mL	5.36 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hashimoto The influence of P2Y₁₂ receptor deficiency on the platelet inhibitory activities of pras. in a mouse model: evidence for specific inhibition of P2Y₁₂ receptors by pras. Biochem.Pharmacol. 2007 PMID: 17681285
• Huber Prasugrel. Nat.Rev.Drug Discov. 2009 PMID: 19483707
• Sugidachi The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties. Br.J.Pharmacol. 2000 PMID: 10742300

Product Documents for Prasugrel