[Pro3]-GIP (Rat)
Description: High affinity rat GIP partial agonist
Biological Activity
[Pro3]-GIP (Rat) is a high affinity rat GIP receptor partial agonist (Kd = 13 nM). Increases cAMP accumulation in COS-7 cells transfected with rat GIP receptor, while also acting as a competitive antagonist of GIP.Technical Data
M.Wt:
4970.63
Formula:
C226H343N61O64S
Sequence:
YAPGTFISDYSIAMDKIRQQDFVNWLLAQKGKKNDWKHNLTQ
Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Species-specific action of (Pro3)GIP - a full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors.
Sparre-Ulrich et al.
Br.J.Pharmacol., 2016;173:27
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