PS 1145 dihydrochloride
Chemical Name: N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride
Biological ActivityPS 1145 dihydrochloride is a selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). Has no effect on PKA, PKC and CKII activity. Inhibits IκB-α phosphorylation and NFκB activation in HeLa cells. Inhibits NFκB-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF-α production in vivo. Orally active.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel IKK inhibitors: beta-carbolines.
Castro et al.
Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors.
Newton et al.
NF-kappa B as a therapeutic target in multiple myeloma.
Hideshima et al.
Citations for PS 1145 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for PS 1145 dihydrochloride include:
4 Citations: Showing 1 - 4
NF-κB memory coordinates transcriptional responses to dynamic inflammatory stimuli.
Authors: Savas Et al.
Cell Rep 2022;40:111159
Induction of IDO1 and Kynurenine by Serine Proteases Subtilisin, Prostate Specific Antigen, CD26 and HtrA: A New Form of Immunosuppression?
Authors: L Gail Et al.
Front Immunol 2022;13:832989
The cell polarity kinase Par1b/MARK2 activation selects specific NF-kB transcripts via phosphorylation of core mediator Med17/TRAP80.
Authors: Anastasia Et al.
Mol Biol Cell 2021;32:690-702
Loss of the oncogenic phosphatase PRL-3 promotes a TNF-R1 feedback loop that mediates triple-negative breast cancer growth.
Authors: Gari Et al.
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