Pyr3

Tocris Bioscience | Catalog # 3751

Selective TRPC3 inhibitor
Tocris Bioscience

Key Product Details

Description

Selective TRPC3 inhibitor
View all TRPC Channel Blockers »

Product Description

Pyr3 is a selective antagonist of the canonical transient receptor potential channel 3 (TRPC3). Inhibits TRPC3-mediated Ca2+ influx (IC50 = 0.7 μM) and suppresses activation of nuclear factor of activated T cells (NFAT). Inhibits hypertrophic responses in cardiomyocytes.

Product Specifications for Pyr3

Molecular Weight

456.63

Formula

C16H11Cl3F3N3O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

CAS Number

1160514-60-2

PubChem ID

56964346

InChI Key

RZHGONNSASQOAY-UHFFFAOYSA-N

SMILES

O=C(/C(Cl)=C(Cl)\Cl)NC(C=C2)=CC=C2N1N=CC(C(OCC)=O)=C1C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.66 100

Preparing Stock Solutions for Pyr3

The following data is based on the product molecular weight 456.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.95 mL 21.90 mL
5 mM 0.44 mL 2.19 mL 4.38 mL
10 mM 0.22 mL 1.09 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 36 publications citing the usage of this product.

  • Kiyonaka Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc.Natl.Acad.Sci.

Product Documents for Pyr3

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Pyr3

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Pyr3 (1)

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  • Pyr3, a selective TRPC3 channel blocker in mesangial cell
    Name: Hitesh Soni
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Mesangial Cell
    Verified Customer | Posted 01/04/2018
    For in vitro study to block the TRP ion channel and elucidate the mechanism of proliferation of mesangial cells under normal and high glucose conditions and to understand the role of TRP ion channels in diabetic nephropathy.
    Pyr3 3751

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