Pyridostatin pentahydrochloride

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Pyridostatin pentahydrochloride | CAS No. 1781882-65-2 | Cell Cycle Inhibitors
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Description: Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest

Chemical Name: 4-(2-Aminoethoxy)N2,N6-bis[(4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinecarboxamide pentahydrochloride

Purity: ≥95%

Product Details
Citations (1)

Biological Activity

Binds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (Kd = 490 nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).

Technical Data

Soluble to 20 mM in water
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Pyridostatin pentahydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Pyridostatin pentahydrochloride include:

1 Citation: Showing 1 - 1

  1. Inosine Substitutions in RNA Activate Latent G-Quadruplexes.
    Authors: Sven Et al.
    J Am Chem Soc  2021;143:15120-15130


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