Pyrimethamine

Key Product Details

Product Description

Pyrimethamine is a potent inhibitor of multidrug and toxin extrusion (MATE) transporters (K_i values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR) and STAT3. Decreases proliferation of human autosomal dominant polycystic kidney disease cells.

Product Specifications for Pyrimethamine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Pyrimethamine

The following data is based on the product molecular weight 248.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.02 mL	20.10 mL	40.21 mL
5 mM	0.80 mL	4.02 mL	8.04 mL
10 mM	0.40 mL	2.01 mL	4.02 mL
50 mM	0.08 mL	0.40 mL	0.80 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Zimmerman Competitive inhibition of folate absorption by dihydrofolate reductase inhibitors, trimeth. and pyrimeth. Am.J.Clin.Nutr. 1987 PMID: 3630970
• Takakura Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. Hum.Mol.Genet. 2011 PMID: 21821671
• Ito Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimeth. J.Pharmacol.Exp.Ther. 2010 PMID: 20065018

Product Documents for Pyrimethamine