Pyroxamide
Discontinued Product
Chemical Name: N-Hydroxy-N'-3-pyridinyloctanediamide
Purity: ≥98%
Biological Activity
Pyroxamide is an inhibitor of histone deacetylase (HDAC); potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).
Carrillo et al.
Bioorg.Med.Chem., 2015;23:5151 -
Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase.
Butler et al.
Clin.Cancer Res., 2001;7:962 -
Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates.
Remiszewski et al.
J.Med.Chem., 2002;45:755 -
Chemical phylogenetics of histone deacetylases.
Bradner et al.
Nat.Chem.Biol., 2010;6:238
Product Datasheets
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Citation for Pyroxamide
The citations listed below are publications that use Tocris products. Selected citations for Pyroxamide include:
1 Citation: Showing 1 - 1
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Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition.
Authors: Kim
Br J?Cancer 2018;118(10):1359
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