Pyrrolidinedithiocarbamate ammonium

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. IL-17A causes depression-like symptoms via NF?B and p38MAPK signaling pathways in mice: Implications for psoriasis associated depression
   A Nadeem, SF Ahmad, NO Al-Harbi, AS Fardan, AM El-Sherbee, KE Ibrahim, SM Attia
   Cytokine, 2017;97(0):14-24.
3. Neuropilin-1 is expressed by breast cancer stem-like cells and is linked to NF-kappaB activation and tumor sphere formation.
   Glinka Y, Mohammed N, Subramaniam V, Jothy S
   Biochem. Biophys. Res. Commun., 2012;425(4):775-80.
4. Tumour necrosis factor-alpha regulates human eosinophil apoptosis via ligation of TNF-receptor 1 and balance between NF-kappaB and AP-1.
   Kankaanranta H, Ilmarinen P, Zhang X, Adcock I, Lahti A, Barnes P, Giembycz M, Lindsay M, Moilanen E
   PLoS ONE, 2014;9(2):e90298.
5. Pharmacological inhibition of macrophage toll-like receptor 4/nuclear factor-kappa B alleviates rhabdomyolysis-induced acute kidney injury
   RS Huang, JJ Zhou, YY Feng, M Shi, F Guo, SJ Gou, S Salerno, L Ma, P Fu
   Chin. Med. J., 2017;0(0):.
6. GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes.
   Lee E, Sidoryk-Wegrzynowicz M, Wang N, Webb A, Son D, Lee K, Aschner M
   J Biol Chem, 2012;287(32):26817-28.
7. Multifactorial Experimental Design to Optimize the Anti-Inflammatory and Proangiogenic Potential of Mesenchymal Stem Cell Spheroids
   KC Murphy, J Whitehead, PC Falahee, D Zhou, SI Simon, JK Leach
   Stem Cells, 2017;0(0):.
8. Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes.
   Bessho et al.
   Biochem.Pharmacol., 1994;48:1883
9. Pyrrolidine dithiocarbamate differentially affects 1β- and cAMP-induced NO-synthase expression in rat renal mesangial cells.
   Eberhardt et al.
   Biochem.Biophys.Res.Commun., 1994;200:163
10. Pyrrolidine dithiocarbamate selectively prevents the expression of the inducible nitric oxide synthase in the rat aorta.
    Schini-Kerth
    Eur.J.Pharmacol., 1994;265:83

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