QAQ dichloride

Key Product Details

Product Description

QAQ dichloride is a photoswitchable Na_v, Ca_v and K_v channel blocker. Blocks channels in the trans conformation. Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Normally membrane impermeant, but enters nociceptive neurons via ion channels activated by noxious stimuli, particularly TRPV1. Exhibits optically reversible local anesthesia in rats.

Product Specifications for QAQ dichloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for QAQ dichloride

The following data is based on the product molecular weight 567.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.52 mL	17.62 mL	35.24 mL
2.5 mM	0.70 mL	3.52 mL	7.05 mL
5 mM	0.35 mL	1.76 mL	3.52 mL
25 mM	0.07 mL	0.35 mL	0.70 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Banghart MR Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 2009 PMID:  19882609
• Mourot Rapid optical control of nociception with an ion-channel photoswitch. Nat.Methods 2012 PMID: 22343342

Product Documents for QAQ dichloride