QNZ 46

Key Product Details

Product Description

QNZ 46 is a GluN2C/GluN2D-selective NMDA receptor non-competitive antagonist (IC₅₀ values are 3, 6, 229, and >300, >300 μM for GluN2D, GluN2C, GluN2A, GluN2B, and GluR1, respectively). Requires binding of glutamate to the GluN2 subunit.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Product Specifications for QNZ 46

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for QNZ 46

The following data is based on the product molecular weight 443.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.55 mL	112.76 mL	225.52 mL
0.5 mM	4.51 mL	22.55 mL	45.10 mL
1 mM	2.26 mL	11.28 mL	22.55 mL
5 mM	0.45 mL	2.26 mL	4.51 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

• Hansen and Traynelis Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J.Neurosci. 2011 PMID: 21389220
• Mosley Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-MthD.-aspartate receptor antagonists. J.Med.Chem. 2010 PMID: 20684595

Product Documents for QNZ 46