QS 11

Tocris Bioscience | Catalog # 3324

ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling
Tocris Bioscience

Key Product Details

Description

ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling
View all ARF GTPase Inhibitors »

Product Description

QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.

Product Specifications for QS 11

Molecular Weight

567.68

Formula

C36H33N5O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol

CAS Number

944328-88-5

PubChem ID

42623900

InChI Key

DOKZLKDGUQWMSX-HKBQPEDESA-N

SMILES

OC[C@H](CC6=CC=CC=C6)NC1=C2C(N(CC3=CC=C(C7=CC=CC=C7)C=C3)C=N2)=NC(OC4=CC=C(CCC5)C5=C4)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 56.77 100
Ethanol 56.77 100

Preparing Stock Solutions for QS 11

The following data is based on the product molecular weight 567.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.76 mL 8.81 mL 17.62 mL
5 mM 0.35 mL 1.76 mL 3.52 mL
10 mM 0.18 mL 0.88 mL 1.76 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for QS 11

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for QS 11

For research use only

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