QX 314 bromide

Tocris Bioscience | Catalog # 1014

Na+ channel blocker
Tocris Bioscience

Key Product Details

Description

Na+ channel blocker
View all Voltage-gated Sodium Channel Blockers »

Product Description

QX 314 bromide is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels. Intracellular QX 314 bromide also inhibits calcium currents in hippocampal CA1 pyramidal neurons.

Product Specifications for QX 314 bromide

Molecular Weight

343.31

Formula

C16H27N2OBr

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide

CAS Number

24003-58-5

PubChem ID

9884487

InChI Key

DLHMKHREUTXMCH-UHFFFAOYSA-N

SMILES

[Br-].CC[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100

Preparing Stock Solutions for QX 314 bromide

The following data is based on the product molecular weight 343.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.91 mL 14.56 mL 29.13 mL
5 mM 0.58 mL 2.91 mL 5.83 mL
10 mM 0.29 mL 1.46 mL 2.91 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 77 publications citing the usage of this product.

Product Documents for QX 314 bromide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for QX 314 bromide

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for QX 314 bromide (1)

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  • QX-314 bromide blocks action potentials propagation
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    Verified Customer | Posted 08/17/2019
    QX-314 was used to block voltage-gated sodium channels, i.e. prevent action potential propagation. The compound develops its effect in 1 microM concentration, in use-dependent mode. Figure: EPSC evoked by electrical stimulation in hippocampal pyramidal neuron at positive membrane potential (+40 mV); QX-314 is added to intracellular solution.
    QX 314 bromide 1014

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