(R)-(-)-Apomorphine hydrochloride

Key Product Details

Product Description

(R)-(-)-Apomorphine hydrochloride is a prototypical dopamine agonist (pK_i values are 6.43, 7.08, 7.59, 8.36 and 7.83 for human recombinant D₁, D_2L, D₃, D₄ and D₅ receptors respectively). Produces biphasic effects on locomotor activity, and displays anti-Parkinsonian and neuroprotective actions following systemic administration in vivo.

Product Specifications for (R)-(-)-Apomorphine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (R)-(-)-Apomorphine hydrochloride

The following data is based on the product molecular weight 303.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.29 mL	16.46 mL	32.92 mL
5 mM	0.66 mL	3.29 mL	6.58 mL
10 mM	0.33 mL	1.65 mL	3.29 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

• Grunblatt Apomorphine protects against MPTP-induced neurotoxicity in mice. Mov.Disord. 1999 PMID: 10435498
• Millan Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J.Pharmacol.Exp.Ther. 2002 PMID: 12388666
• Liu Low doses of apomor. suppress operant motor performance in rats. Pharmacol.Biochem.Behav. 1996 PMID: 8808141

Product Documents for (R)-(-)-Apomorphine hydrochloride