Cathepsin A/lyososomal carboxypeptidase A is a member of the serine carboxypeptidase family (1). Cathepsin A is a multifunctional enzyme that expresses deaminidase and esterase activities at neutral pH and carboxypeptidase activity at acidic pH. Also known as protective protein, its association with beta -galactosidase ( beta -gal) and neuraminidase is essential for beta -gal stability and neuraminidase activation in the lysosomes. Inherited deficiency of Cathepsin A causes the lysosomal storage disorder galactosialidosis, characterized by a combined secondary deficiency of beta -gal and neuraminidase. Cathepsin A is capable of hydrolyzing a variety of bioactive peptide hormones including tachykinins, indicating that extralysosomal Cathepsin A plays a role in regulation of functions of these molecules (2). Cathepsin A is synthesized as a single-chain precursor and processed into heavy (32 kDa) and light (20 kDa) chains, which are linked by disulfide bonds.
Recombinant Human Cathepsin A/Lysosom Carboxypeptidase A, CF
R&D Systems | Catalog # 1049-SE
Key Product Details
- R&D Systems NS0-derived Recombinant Human Cathepsin A/Lysosom Carboxypeptidase A (1049-SE)
- Quality control testing to verify active proteins with lot specific assays by in-house scientists
- All R&D Systems proteins are covered with a 100% guarantee
Source
Accession Number
Structure / Form
Applications
Product Specifications
N-terminal Sequence Analysis
Predicted Molecular Mass
SDS-PAGE
Formulation, Preparation, and Storage
1049-SE
| Formulation | Supplied as a 0.2 μm filtered solution in Tris and NaCl. |
| Shipping | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date. |
Background: Cathepsin A/Lysosomal Carboxypeptidase A
References
- Pshezhetsky, A.V. (2004) in Handbook of Proteolytic Enzymes (ed. Barrett, A.J. et al.) p. 1923, Academic Press, San Diego.
- Hiraiwa, M. (1999) Cell. Mol. Life. Sci. 56:894.
Alternate Names
Gene Symbol
UniProt
Additional Cathepsin A/Lysosomal Carboxypeptidase A Products
- All Products for Cathepsin A/Lysosomal Carboxypeptidase A
- Cathepsin A/Lysosomal Carboxypeptidase A cDNA Clones
- Cathepsin A/Lysosomal Carboxypeptidase A ELISA Kits
- Cathepsin A/Lysosomal Carboxypeptidase A Lysates
- Cathepsin A/Lysosomal Carboxypeptidase A Primary Antibodies
- Cathepsin A/Lysosomal Carboxypeptidase A Proteins and Enzymes
Product Documents for Recombinant Human Cathepsin A/Lysosom Carboxypeptidase A, CF
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Recombinant Human Cathepsin A/Lysosom Carboxypeptidase A, CF
For research use only
Related Research Areas
Citations for Recombinant Human Cathepsin A/Lysosom Carboxypeptidase A, CF
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FAQs for Recombinant Human Cathepsin A/Lysosom Carboxypeptidase A, CF
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Q: Where does Cathepsin A cleave Mca-RPPGFSAFK(Dnp)-OH Fluorogenic Peptide Substrate, Catalog # ES005?
A: Although the QC assay conditions provided on our recombinant Cathepsin A datasheets should favor carboxypeptidase activity, it is possible that there is more than one site in the ES005 peptide recognized and cleaved by Cathepsin A. We have not performed verification experiments to confirm the cleavage site preferred in our reaction conditions.