Recombinant Human LRRTM1 Fc Chimera Protein, CF

Recombinant Human LRRTM1 Fc Chimera Protein, CF Summary

• R&D Systems CHO-derived Recombinant Human LRRTM1 Fc Chimera Protein (10372-LR)
• Quality control testing to verify active proteins with lot specific assays by in-house scientists
• All R&D Systems proteins are covered with a 100% guarantee

Product Specifications

Product Datasheets

Carrier Free

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

Background: LRRTM1

Human LRRTM1 (leucine-rich repeat transmembrane neuronal 1) is a 58-59 kDa (predicted) type I transmembrane protein, that belongs to the LRRTM family of proteins within the leucine-rich repeat (LRR) superfamily (1). It is synthesized as a precursor with a 34 amino acid (aa) signal sequence, a 393 aa luminal region, a 21 aa transmembrane region, and a 74 aa cytoplasmic region. The luminal portion of LRRTM1 contains three N-linked glycosylation sites and 10 LRRs flanked by cysteine-rich domains (1). The cytoplasmic region contains several tyrosine, serine, and threonine residues that have potential to be phosphorylated and thus to be involved in signal transduction (1). The C-terminal also contains a conserved glutamic acid-cysteine-glutamic acid-valine sequence for potential interaction with PDZ proteins (1-2). Mature human LRRTM1 is 97% aa identical to mouse LRRTM1. LRRTM1 is expressed in both developing and adult brains. It can be detected in many brain areas such the forebrain, mid brain, olfactory bulb, striatum, thalamus and cerebral cortex (3). LRRTM1 proteins are mainly localized to postsynaptic sites and bind across the synaptic cleft to its presynaptic partner neurexins lacking the splice site 4 insert (3, 4). LRRTM1 functions as a synapse organizer and plays an essential role in synapse formation and development (3, 4). Functionally, LRRTM1 may be involved in the formation of the CNS and maintenance of CNS structure and function in the adult brain (1). In addition, LRRTM1 has been shown to be a maternally suppressed gene that is associated paternally with handedness and schizophrenia (3). LRRTM1 was also reported to be associated with schizophrenia and autism spectrum disorder (5, 6).

Related Research Areas

• Activin Family