Recombinant Human Mer Fc Chimera Protein, CF

R&D Systems | Catalog # 891-MR

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Key Product Details

  • R&D Systems Sf 21 (baculovirus)-derived Recombinant Human Mer Fc Chimera Protein (891-MR)
  • Quality control testing to verify active proteins with lot specific assays by in-house scientists
  • All R&D Systems proteins are covered with a 100% guarantee

Source

Sf 21 (baculovirus)

Accession Number

AAB60430.1

Structure / Form

Disulfide-linked homodimer

Applications

Binding Activity
View all Mer Proteins and Enzymes »

Product Specifications

Source

Spodoptera frugiperda, Sf 21 (baculovirus)-derived human Mer protein
Human Mer
(Arg26-Ala499)
Accession # AAB60430.1		 IEGRMD Human IgG1
(Pro100-Lys330)
N-terminus C-terminus

Purity

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Arg26

Predicted Molecular Mass

78 kDa (monomer)

SDS-PAGE

100-110 kDa, reducing conditions

Activity

Measured by its binding ability in a functional ELISA.
Immobilized Recombinant Human (rh) Mer Fc Chimera at 10 µg/mL (100 µL/well) can bind rhGas6 (Catalog # 885-GSB) with a linear range of 0.03-1 µg/mL.

Reviewed Applications

Read 3 reviews rated 4.7 using 891-MR in the following applications:

Formulation, Preparation, and Storage

891-MR
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution

Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Mer

Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Recent studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions.

References

  1. Nagata, K. et al. (1996) J. Biol. Chem. 22:30022.
  2. Crosier, K.E. and P.S Crosier (1997) Pathology 29:131.

Long Name

Receptor Tyrosine Protein Kinase Mer

Alternate Names

c-Eyk, C-mer, MerTK

Entrez Gene IDs

10461 (Human); 17289 (Mouse); 102143798 (Cynomolgus Monkey)

Gene Symbol

MERTK

UniProt

AAB60430.1

Additional Mer Products

Product Documents for Recombinant Human Mer Fc Chimera Protein, CF

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Recombinant Human Mer Fc Chimera Protein, CF

For research use only

Citations for Recombinant Human Mer Fc Chimera Protein, CF

Customer Reviews for Recombinant Human Mer Fc Chimera Protein, CF (3)

4.7 out of 5
3 Customer Ratings
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  • Recombinant Human Mer Fc Chimera Protein, CF
    Name: Anonymous
    Application: In vitro bioactivity in cell culture
    Verified Customer | Posted 11/12/2020
  • Recombinant Human Mer Fc Chimera Protein, CF
    Name: Anonymous
    Application: Binding assay/Protein-protein interaction
    Verified Customer | Posted 04/03/2018
    Recombinant Human Mer Fc Chimera Protein, CF 891-MR
  • Recombinant Human Mer Fc Chimera Protein, CF
    Name: Anonymous
    Application: Immunoassay Standard
    Verified Customer | Posted 03/23/2018
    Recombinant Human Mer Fc Chimera Protein, CF 891-MR

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