Resiquimod

Tocris Bioscience | Catalog # 4536

Toll-like receptor 7 (TLR7) agonist
Tocris Bioscience

Key Product Details

Description

Toll-like receptor 7 (TLR7) agonist

Alternative Names

R 848
View all Toll-like Receptor Agonists »

Product Description

Resiquimod is a toll-like receptor 7 (TLR7) agonist. Induces upregulation of IL-6, IL-12, IFN-γ and iNOS expression in mouse bone marrow-derived macrophages (BMMs). Inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Also promotes the differentiation of MDSCs into macrophages and dendritic cells. Proinflammatory and antiviral.

Product Specifications for Resiquimod

Molecular Weight

314.38

Formula

C17H22N4O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol

CAS Number

144875-48-9

PubChem ID

159603

InChI Key

BXNMTOQRYBFHNZ-UHFFFAOYSA-N

SMILES

NC1=C3C(N(CC(C)(O)C)C(COCC)=N3)=C2C(C=CC=C2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.44 100
Ethanol 6.29 20

Preparing Stock Solutions for Resiquimod

The following data is based on the product molecular weight 314.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.18 mL 15.90 mL 31.81 mL
5 mM 0.64 mL 3.18 mL 6.36 mL
10 mM 0.32 mL 1.59 mL 3.18 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 23 publications citing the usage of this product.

Product Documents for Resiquimod

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Resiquimod

For research use only

Customer Reviews for Resiquimod (1)

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  • Good, stores well
    Name: Scott Scarneo
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: BMDM
    Verified Customer | Posted 02/06/2019
    Worked well for macrophages and got the desired result by TNF production.
    Resiquimod 4536

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