Ribavirin

Tocris Bioscience | Catalog # 4501

Blocks eIF4E activity; antiviral guanosine analog
Tocris Bioscience

Key Product Details

Description

Blocks eIF4E activity; antiviral guanosine analog
View all Protein-synthesizing GTPase Compounds »

Product Description

Ribavirin is an antiviral guanosine ribonucleoside analog; misincorporated into mRNA by viral-dependent RNA polymerases. Binds to and redistributes mammalian eIF4E from the nucleus to the cytoplasm (Ki ~ 0.3 μM for the active metabolite, ribavirin triphosphate). Also inosine monophosphate dehydrogenase (IMPDH) inhibitor. Represses colony formation of primary AML-M5 progenitor cells (IC50 ~ 1 μM); reduces disease severity in acute myeloid leukemia (AML). Inhibits cytopathic effect of SARS-CoV in Vero cells in vitro. Orally available.

Product Specifications for Ribavirin

Molecular Weight

244.20

Formula

C8H12N4O5

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-β-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide

CAS Number

36791-04-5

PubChem ID

37542

InChI Key

IWUCXVSUMQZMFG-AFCXAGJDSA-N

SMILES

O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC(C(N)=O)=N2)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 24.42 100
DMSO 24.42 100

Preparing Stock Solutions for Ribavirin

The following data is based on the product molecular weight 244.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.10 mL 20.48 mL 40.95 mL
5 mM 0.82 mL 4.10 mL 8.19 mL
10 mM 0.41 mL 2.05 mL 4.10 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for Ribavirin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ribavirin

For research use only

⚠ WARNING: This product can expose you to chemicals including Ribavirin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Customer Reviews for Ribavirin (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used Ribavirin?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card
Showing  1 - 1 的 1 review Showing All
Filter By:
Clear Filters X
  • Used as an IMPDH inhibitor
    Name: Timothy Ryan
    Species: Rat
    Assay Type: Ex Vivo
    Cell Line/Tissue: Primary hippocampal neurons
    Verified Customer | Posted 09/30/2024
    The drug was incubated at 2 μM for 2 h to deplete intracellular GTP.

There are no reviews that match your criteria.

Showing  1 - 1 的 1 review Showing All